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17 Best Startups in Saint Paul Minnesota to Watch in 2025

The Definitive ÐÓ°ÉÔ­´´ Ranking of Startups in Saint Paul Minnesota

We track 71,000+ companies and rank them dynamically using our ÐÓ°ÉÔ­´´ Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 17 start-ups with an aggregate funding of $395.5m. The average funding per company in this subset is $23.3m.

Last update to the database: Feb 18, 2025. See changelog.

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11

Funding Rounds

$67.4m

Money raised

Recombinetics is a biotechnology company that uses gene editing for agriculture and medicine

4

Funding Rounds

$224.0m

Money raised

Developer of a human resource management platform designed to help hourly employees and managers work better together.

2

Funding Rounds

$2.8m

Money raised

AI assistant designed to break down food science, consumer insights, marketing research, and more

1

Funding Rounds

$1.3m

Money raised

Developer of a finance platform intended to connect the entire agricultural chain to the capital market.

1

Funding Rounds

$682.2k

Money raised

A company developing diagnostic device and software for the detection and treatment of vascular disease

4

Funding Rounds

$27.9m

Money raised

A company developing medical diagnostic products

1

Funding Rounds

$1.5m

Money raised

ilos videos is a Saint Paul, Minnesota-based company founded in 2012 by Nick Stokman, Peter Fares and Sean Higgins.

1

Funding Rounds

$256.0k

Money raised

Silicon Prairie Online is a Saint Paul, Minnesota-based company founded in 2016 by David Duccini.

Key people:

1

Funding Rounds

$2.0m

Money raised

Phenomix Sciences LLC is a Saint Paul, Minnesota-based biotechnology company developing genomic testing services and systems for the personalized management of chronic diseases.

1

Funding Rounds

$52.0m

Money raised

Galil Medical is a Saint Paul, Minnesota-based company.

5

Funding Rounds

$6.0m

Money raised

BetterTime Co. is a Saint Paul, Minnesota-based wellness company founded in 2018.

1

Funding Rounds

$1.8m

Money raised

Topical therapies that condition damaged tissue and control microbial biofilms

1

Funding Rounds

$1.2m

Money raised

Oppsource is a Saint Paul, Minnesota-based company founded in 2008.

1

Funding Rounds

$500.0k

Money raised

Offeringtree Sbc is a company founded in 2016.

1

Funding Rounds

$1.3m

Money raised

Reflection Sciences, Inc. is a Saint Paul, Minnesota-based education company founded in 2014.

Industries:

1

Funding Rounds

$4.0m

Money raised

Aryeo, Inc. is a Saint Paul, Minnesota-based company founded in 2019.

1

Funding Rounds

$850.0k

Money raised

Oncodea Corp is a Saint Paul, Minnesota-based company founded in 2021.

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